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Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus

2008; Wiley; Volume: 35; Issue: 3 Linguagem: Inglês

10.1111/j.1600-051x.2007.01191.x

1600-051X

Giovanni Corrocher, Gabriele Di Lorenzo, Nicola Martinelli, Pasquale Mansueto, Domenico Biasi, Pier Francesco Nocini, Giorgio Lombardo, Andrea Fior, Roberto Corrocher, Lisa Maria Bambara, Stefano Gelio, Maria Luisa Pacor,

Cancer and Skin Lesions

Abstract Background: Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity. Objective: We compared tacrolimus 0.1% ointment and clobetasol 0.05% ointment for the treatment of OLP. Patients and Methods: A total of 32 patients (20 females and 12 males; all white, Italian origin, mean age of 43.6±18.4 years; 16 patients per treatment group) were treated with tacrolimus or clobetasol ointment for 4 weeks in a randomized, double‐blind, clinical trial. Pain severity, burning sensation, and mucosal lesion extension were assessed using a four‐point scale. Results: At the end of the treatment period, symptom scores were significantly lower in the tacrolimus group than in the clobetasol group. Conclusion: The results of this study suggest that tacrolimus 0.1% ointment is more effective than clobetasol propionate 0.05% ointment in the treatment of OLP. However, other studies are needed to confirm the effectiveness of this treatment before it can be recommended for use in clinical practice.