N-methyltyramine: Formation in Opuntia clavata and metabolism in Coryphantha macromeris var. Runyonii
1980; Elsevier BV; Volume: 19; Issue: 3 Linguagem: Inglês
10.1016/0031-9422(80)83191-8
ISSN1873-3700
Autores Tópico(s)Chemical synthesis and alkaloids
Resumo-Administration of tyramine-[1-14C] to Opuntia clavata resulted in the formation of labeled N-methyltyramine. This procedure established the biosynthetic origin of the major alkaloid in this cactus as well as providing a radiolabeled chemical that was not commercially available. The N-methyltyramine-[1-14C] was in turn administered to Coryphantha macromeris var. runyonii to determine its metabolic role in the biosynthesis of the psychoactive cactus alkaloid normacromerine (N-methyl-3,4-dimethoxy-β-hydroxyphenethylamine). This feeding experiment established N-methyltyramine as a precursor to normacromerine.
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