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Non-pathogenic Anti-Desmoglein 3 IgG Autoantibodies in Fogo Selvagem

2006; Elsevier BV; Volume: 126; Issue: 9 Linguagem: Inglês

10.1038/sj.jid.5700457

1523-1747

Masayuki Amagai,

Urticaria and Related Conditions

The endemic form of pemphigus foliaceus, fogo selvagem, is caused by IgG autoantibodies directed against desmoglein 1 (Dsg1). Hilario-Vargas and his colleagues describe a high prevalence of IgG autoantibodies against Dsg3, the target antigen of pemphigus vulgaris, in a Brazilian population where fogo selvagem is endemic, although those patients do not develop any apparent clinical phenotype of pemphigus vulgaris.