Hafnium (IV) bis(perfluorooctanesulfonyl)imide complex catalyzed synthesis of polyhydroquinoline derivatives via unsymmetrical Hantzsch reaction in fluorous medium
2009; Elsevier BV; Volume: 131; Issue: 1 Linguagem: Inglês
10.1016/j.jfluchem.2009.10.009
ISSN1873-3328
AutoresMei Hong, Chun Cai, Wenbin Yi,
Tópico(s)Quinazolinone synthesis and applications
ResumoA facile and efficient synthesis of polyhydroquinoline derivatives was reported via four-component condensation reaction of aldehydes, dimedone, active methylene compounds, and ammonium acetate in the presence of Hf(NPf2)4 in C10F18 at 60 °C. The method offers several advantages including high yields, short reaction time, simple work-up procedure and catalyst reusability.
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