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An NMDA-mediated component of excitatory synaptic input to dentate granule cells in ‘epileptic’ human hippocampus studied in vitro

1990; Elsevier BV; Volume: 515; Issue: 1-2 Linguagem: Inglês

10.1016/0006-8993(90)90615-i

1872-6240

László Urbán, Peter G. Aitken, A. Friedman, George G. Somjen,

Photoreceptor and optogenetics research

Recordings were made from human hippocampal tissue surgically removed for treatment of epilepsy. In 70% of cases, anN-methyl-d-asparte (NMDA) receptor-mediated component was present in excitatory synaptic input to gyrus dentatus. NMDA receptors are normally present, but do not participate in low-frequency synaptic transmission, in this region of the mammalian brain. These findings suggest that recruitment of normally dormant excitatory amino acid receptors may be a feature of the epileptic brain.