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3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation

2005; Elsevier BV; Volume: 15; Issue: 9 Linguagem: Inglês

10.1016/j.bmcl.2005.03.024

1464-3405

Ronghui Lin, Yanhua Lü, Steven K. Wetter, Peter J. Connolly, Ignatius J. Turchi, William V. Murray, Stuart L. Emanuel, Robert H. Gruninger, Angel R. Fuentes‐Pesquera, Mary Adams, Niranjan B. Pandey, Sandra Moreno-Mazza, Steven A. Middleton, Linda K. Jolliffe,

Advanced Breast Cancer Therapies

A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.