Pharmacological investigation of γ-aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat
1981; Elsevier BV; Volume: 74; Issue: 3 Linguagem: Inglês
10.1016/0014-4886(81)90255-7
ISSN1090-2430
AutoresMichael Kalichman, Kenneth E. Livingston, W. McIntyre Burnham,
Tópico(s)Anesthesia and Neurotoxicity Research
ResumoThe effect of GABA agonists and antagonists on the rate of kindled seizure development was studied in rats. Drugs and drug doses were selected to modify GABA function by a variety of mechanisms. In the drug treatment groups, drugs were administered daily before kindling stimulation, and matched control groups received only drug vehicle before stimulation. Kindling development was (i) accelerated by the GABA-synthesis inhibitor 3-mercaptopropionic acid (20 mg/kg) and the GABA antagonist bicuculline (2.5 mg/kg); (ii) retarded by pentobarbital (5 mg/kg); and (iii) not altered by the GABA-response antagonist picrotoxin (2 mg/kg), the GABA agonist imidazole acetic acid (100 mg/kg), or the GABA metabolism inhibitor γ-vinyl GABA (100 mg/kg). These results are interpreted as evidence that endogenous GABA may play a role in opposing kindled seizure development, but that the mechanism of that development does not primarily involve failure of the GABA system.
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