Interferon‐mediated intracellular signalling Modulation of different phospholipase activities in Burkitt lymphoma cells
1992; Wiley; Volume: 313; Issue: 3 Linguagem: Inglês
10.1016/0014-5793(92)81193-p
ISSN1873-3468
AutoresAmelia Cataldi, R. Rana, Roberto Di Primio, Renato Bareggi, R. Lisio, Noura A. Toto, Sebastianó Miscia,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoThe effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.
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