Influence of baclofen upon the alpha‐motoneuron in spasticity by means of f‐wave analysis
1995; Wiley; Volume: 18; Issue: 1 Linguagem: Inglês
10.1002/mus.880180114
ISSN1097-4598
AutoresJ. Dressnandt, Carola Auer, B. Conrad,
Tópico(s)Neurological disorders and treatments
ResumoAbstract Intrathecal baclofen dramatically improves severe spastic syndromes. This improvement is likely related to reduced excitability of alphamotoneurons. To investigate the influence of baclofen upon the alphamotoneuron, we analyzed F‐waves before and after intrathecal baclofen bolus injection (usually 50 μg) as well as after administration of different, constantly delivered doses (60–200 μg/day). Intrathecal baclofen bolus decreased the maximum F‐wave amplitude (F p ) from an initial value of 9% of the maximum M amplitude (M max ) (=F/M‐ratio) to 2.4% of the M max after 130–180 min, reduced the mean F‐wave amplitude 60% within 150 min, and shortened the mean duration by 40–60% after 130–180 min. Constantly delivered baclofen of 100 μg/day reduced the F/M‐ratio from 5% to 2%, the mean F‐wave amplitude by 40–80%, and the F‐wave mean duration by 40–80%. The minimum F‐wave latency did not change after bolus or during steady state administration. The findings indicate that the F‐wave mean and maximum amplitude as well as the mean duration are altered in a quantifiable manner following intrathecal baclofen application.© 1995 John Wiley &Sons, Inc.
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