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Controlled trial of continuous negative external pressure in the treatment of severe respiratory distress syndrome

1973; Elsevier BV; Volume: 82; Issue: 6 Linguagem: Inglês

10.1016/s0022-3476(73)80418-4

1097-6833

Avroy A. Fanaroff, Chul Choon, Roberto Sosa, Robert S. Crumrine, Marshall H. Klaus,

Neuroscience of respiration and sleep

A sequential controlled trial of continuous negative pressure versus oxygen in treatment of severe respiratory distress syndrome (PaO2 1,000 Gm. and who had no congenital malformations were studied; there were 14 in the oxygen-treated control group and 15 in the CNP-treated group. Following the study, seven additional infants were treated with CNP. Birth weights, sex, gestational ages, ages, and blood gases at the time of admission to the study were similar. Study failure was defined as a PaO2<50 mm. Hg in 100 per cent oxygen, or onset of apnea. Sequential analysis revealed CNP was superior to oxygen (p<0.05): study successes—CNP group, 10 of 15 (67 per cent) and oxygen-treated control group, 2 of 14 (14 per cent). CNP improves oxygenation in RDS and significantly reduces duration of exposure to high oxygen concentration and the need for respirator therapy. The over-all survival rate was 72 per cent. A sequential controlled trial of continuous negative pressure versus oxygen in treatment of severe respiratory distress syndrome (PaO2 1,000 Gm. and who had no congenital malformations were studied; there were 14 in the oxygen-treated control group and 15 in the CNP-treated group. Following the study, seven additional infants were treated with CNP. Birth weights, sex, gestational ages, ages, and blood gases at the time of admission to the study were similar. Study failure was defined as a PaO2<50 mm. Hg in 100 per cent oxygen, or onset of apnea. Sequential analysis revealed CNP was superior to oxygen (p<0.05): study successes—CNP group, 10 of 15 (67 per cent) and oxygen-treated control group, 2 of 14 (14 per cent). CNP improves oxygenation in RDS and significantly reduces duration of exposure to high oxygen concentration and the need for respirator therapy. The over-all survival rate was 72 per cent.