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Dynamic Glycosylation of the Transcription Factor CREB: A Potential Role in Gene Regulation

2003; American Chemical Society; Volume: 125; Issue: 22 Linguagem: Inglês

10.1021/ja028200t

1943-2984

Nathan Lamarre-Vincent, Linda C. Hsieh‐Wilson,

RNA and protein synthesis mechanisms

We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAFII130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.