Portal de Periódicos da CAPES

Steroidal saponins from Asparagus acutifolius

2007; Elsevier BV; Volume: 68; Issue: 20 Linguagem: Inglês

10.1016/j.phytochem.2007.02.033

1873-3700

Marc Sautour, Tomofumi Miyamoto, Marie‐Aleth Lacaille‐Dubois,

Natural product bioactivities and synthesis

Six new steroidal saponins (1–6) were isolated from the roots of A. acutifolius L., together with a known spirostanol glycoside (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS and HRESIMS). Compounds 4–7 demonstrated antifungal activity against the human pathogenic yeasts C. albicans, C. glabrata and C. tropicalis with MICs values between 12.5 and 100 μg/ml.