Efficient One-Pot Conversion of 6-Methyl-2-nitroaniline into 1-Alkyloxy-2-alkyl-4-methyl-, 1-Benzyloxy-2-phenyl-4-Methyl-, and 1-Allyloxy-4-methyl-2-vinyl-benzimidazole
1995; Taylor & Francis; Volume: 25; Issue: 6 Linguagem: Inglês
10.1080/00397919508013418
ISSN1532-2432
AutoresJohn M. Gardiner, Colin R. Loyns,
Tópico(s)Chemical Reaction Mechanisms
ResumoAbstract 6-Methyl-2-nitroaniline reacts with alkyl, benzyl and allyl halides and NaH as base, to afford 1-alkoxy-2-alky1-, 1-benzyloxy-2-ary1- and 1-allyloxy-2-viny1-benzimidazoles in good to excellent yields (73-98%), via a novel one-pot N-alkylation-heterocyclization-O-alkylation sequence.
Referência(s)