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Uber eine hemmung der 5-hydroxytryptamin- und nikotinwirkung am isolierten darm durch adenosinderivate

1964; Elsevier BV; Volume: 13; Issue: 6 Linguagem: Inglês

10.1016/0006-2952(64)90029-2

1873-2968

E. Werle, H. Schievelbein,

Receptor Mechanisms and Signaling

Abstract The contractile effect of 5-hydroxytryptamine (5-HT) and nicotine on the isolated guinea pig ileum is inhibited by adenosine and several adenosine derivatives. The following substances are active inhibitors : ATP, ADP, AMP, adenosine, 3'-adenylic acid, and under specific conditions adenosine-3',5'-phosphate (cyclic 3,5-AMP). Ineffective are adenine, inosine, desoxyadenosine, cytidine, xanthosine and guanosine. The inhibitory derivatives of adenosine do not affect the contractions of the isolated guinea pig ileum caused by histamine, acetylcholine, kallidin, angiotensine and vasopressine. ATP inhibits the contractions of the isolated rabbit ileum, caused by 5-HT and nicotine, but does not inhibit the 5-HT effect on the isolated rat uterus. The effect of 5-HT, angiotensine or noradrenaline on the isolated rabbit aorta is not inhibited by ATP. Angiotensine diminishes the reactivity of the ileum to 5-HT, histamine and angiotensine but not to kallidin. The importance of the results for the differentiation of receptors on the same biological substrate is briefly discussed.