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Recurrence of keratoconus in donor cornea 22 years after successful keratoplasty.

1983; BMJ; Volume: 67; Issue: 1 Linguagem: Inglês

10.1136/bjo.67.1.23

1468-2079

Verinder S. Nirankari, James W. Karesh, F Bastion, Vinod Lakhanpal, Emery E. Billings,

Corneal Surgery and Treatments

We report a second clinico-pathologic report of recurrent keratoconus in a 43-year-old white female with bilateral penetrating keratoplasties for keratoconus.She was found to have a recurrence of this condition in the right eye as manifested by increasing myopic oblique astigmatism, subepithelial and anterior stromal scarring and corneal thinning, 22 years following the initial grafting procedure.A second successful penetrating keratoplasty was performed.Light and electron microscopy demonstrated abnormalities in the basal epithelium, breaks in the base- ment membrane, duplication and thickening of Bowman's layer, and abnormal stromal keratocytes with accumulation of granular intra-and extracellular material.These findings are consistent with changes as seen in keratoconus.Keratoconus is an axial corneal ectasia of obscure aetiology.It has been associated with many systemic and ocular diseases as well as with a variety of inheritance patterns.'Nonetheless, its underlying pathogenesis remains to be explained.Penetrating keratoplasty has been highly successful in treating advanced cases.25 Recurrence of keratoconus following keratoplasty has been pre- viously reported,8 but these reports were on the basis of clinical findings alone.A recent clinicopatho- logical report has also indicated that keratoconus may recur years later in donor graft tissue following a on August 2, 2023 by guest.