Configurational studies on 2-[∝-(2-ethoxyphenoxy)benzyl] morpholine fce 20124
1985; Elsevier BV; Volume: 41; Issue: 7 Linguagem: Inglês
10.1016/s0040-4020(01)96541-x
ISSN1464-5416
AutoresPiero Melloni, A. DELLA TORRE, Ettore Lazzari, G. Mazzini, Maurizio Meroni,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoThe relative configuration of the two diastereoisomers of (±)2-[∢-(2-ethoxyphenoxy)benzyl] morpholine is determined by a synthesis involving regio and stereo specific reactions. (RS,RS) diastereoisomer FCE 20124 was separated into its (+) and (-) enantiomers both by crystallization of the optically active mandelate salt and by a multi-step synthesis from (+)-(2S,3R)-3-phenylglycidic acid.
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