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Synthèse Dans La Série Des Phenanthridines. IV. Préparation De Nouveaux Radioprotecteurs A Motif Phenanthridine

1991; Wiley; Volume: 100; Issue: 2 Linguagem: Inglês

10.1002/bscb.19911000210

0037-9646

Claude Lion, J. P. Boukou‐Poba, Claude Charvy,

Advanced Synthetic Organic Chemistry

Abstract New phenanthridines substituted in the 6‐position by a β‐aminoethylthiol chain have been synthesized. These new products are easily obtained from 6‐methylphenanthridine by a Mannich reaction or from 6‐bromophenanthridine by substitution. From the 6‐carboxaldehydophenanthridine and the β‐amino‐ethylthiol, the corresponding thiazolidine or imine are obtained. These compounds are likely to be new radioprotectors.