Synthesis and structure–property relationship of polyester-urethanes and their evaluation for the regeneration of contractile tissues
2013; Elsevier BV; Volume: 73; Issue: 10 Linguagem: Inglês
10.1016/j.reactfunctpolym.2013.01.006
ISSN1873-166X
AutoresSusanna Sartori, Monica Boffito, Piero Serafini, Andrea Caporale, Antonella Silvestri, Ettore Bernardi, Maria Paola Sassi, Francesca Boccafoschi, Gianluca Ciardelli,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoThe structure–property relationship of degradable polyurethanes from non toxic building blocks was studied by synthesising four different biodegradable poly(ester urethanes) from poly(ε-caprolactone) (PCL) diol, 1,4-diisocyanatobutane and different chain extenders. For instance, the chain extenders were an amino acid derivative diamine, an amino acid derivative diol, a cyclic diol and a custom made diamine, containing an enzymatically degradable peptide (Ala–Ala sequence). Physicochemical and morphological characterisation (SEC, DSC, DMA, AFM) was performed, showing the influence of the chain extender on the polyurethane properties. A correlation between surface domain morphologies and thermal properties was highlighted and a relationship between the biological response and surface morphologies was observed. Collecting mechanical characterisation and myoblast cell culture results together, the polyurethane synthesised with the amino acid derivative diamine resulted the most promising candidate for fabricating scaffolds supporting the regeneration of muscle tissues.
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