Nucleotide C4′ radical fragmentation is base-dependent
1997; Elsevier BV; Volume: 38; Issue: 47 Linguagem: Inglês
10.1016/s0040-4039(97)10249-0
ISSN1873-3581
Autores Tópico(s)Advanced Chemical Physics Studies
ResumoNucleotide C4′ radicals undergo radical ionic fragmentation with expulsion of the 3′-phosphate giving a 3′,4′-radical cation. With a series of mononucleotides it is shown that the rate of this fragmentation is a function of the base (T ∼ G > ABz > A ∼ C) with the least basic, less-hydrogen bonded nucleotides fragmenting more rapidly in aqueous methanol.
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