Adverse Skin Reactions to Anti-TNF-Alpha Monoclonal Antibody Therapy
2003; Karger Publishers; Volume: 206; Issue: 4 Linguagem: Inglês
10.1159/000069965
ISSN1421-9832
AutoresSimon Devos, N. van den Bossche, M. De Vos, J.M. Naeyaert,
Tópico(s)Urticaria and Related Conditions
ResumoVarious adverse cutaneous reactions to anti-TNF-α monoclonal antibody have been reported. In clinical studies with infliximab (Remicade<sup>®</sup>) adverse drug reactions were most frequently reported in the respiratory system and in the skin and appendages. We describe here 6 patients receiving anti- TNF-α therapy (infliximab) for Crohn’s disease or rheumatoid arthritis who consulted our out-patient department for adverse cutaneous reactions between November 1999 and February 2002. The following diagnoses were made: leukocytoclastic vasculitis, lichenoid drug reaction, perniosis-like eruption (2 patients), superficial granuloma annulare and acute folliculitis.
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