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The astrocyte response to γ-aminobutyric acid attenuates with age in the rat optic nerve

1994; Royal Society; Volume: 258; Issue: 1351 Linguagem: Inglês

10.1098/rspb.1994.0134

1471-2954

Arthur M. Butt, Jennifer L. Jennings,

Tryptophan and brain disorders

Restricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Butt Arthur M. and Jennings Jason 1994The astrocyte response to γ-aminobutyric acid attenuates with age in the rat optic nerveProc. R. Soc. Lond. B.2589–15http://doi.org/10.1098/rspb.1994.0134SectionRestricted accessArticleThe astrocyte response to γ-aminobutyric acid attenuates with age in the rat optic nerve Arthur M. Butt Google Scholar Find this author on PubMed Search for more papers by this author and Jason Jennings Google Scholar Find this author on PubMed Search for more papers by this author Arthur M. Butt Google Scholar Find this author on PubMed and Jason Jennings Google Scholar Find this author on PubMed Published:22 October 1994https://doi.org/10.1098/rspb.1994.0134AbstractThere is increasing evidence that glial cells respond to the inhibitory neurotransmitter γ-aminobutyric acid (GABA), and astrocytes have been shown to possess GABAA receptors both in vivo and in vitro. A recent study by Sakatani et al. (Proc. R. Soc. Lond. B 247, 155 (1992)) demonstrated the transient expression of functional GABAA receptors in the developing rat optic nerve, but axonal and glial components of the response were not distinguished. To help address this problem, we have determined the electrophysiological response to GABA in astrocytes of the isolated intact optic nerves from neonatal rats, identified morphologically following intracellular injection of horseradish peroxidase. Astrocytes responded to GABA by a GABAA receptor-mediated depolarization which attenuated gradually during post-natal development; astrocytes in 21-day-old nerves were not observed to respond to GABA. The results indicate the transient presence of functional GABAA receptors in developing rat optic nerve astrocytes in situ, and we speculate upon a role for GABA in glial signalling and the organization of axonglial interrelations during development.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. Previous ArticleNext Article VIEW FULL TEXT DOWNLOAD PDF FiguresRelatedReferencesDetailsCited by Butt A, Fern R and Matute C (2014) Neurotransmitter signaling in white matter, Glia, 10.1002/glia.22674, 62:11, (1762-1779), Online publication date: 1-Nov-2014. Fern R, Matute C and Stys P (2014) White matter injury: Ischemic and nonischemic, Glia, 10.1002/glia.22722, 62:11, (1780-1789), Online publication date: 1-Nov-2014. Vélez-Fort M, Audinat E and Angulo M (2011) Central Role of GABA in Neuron–Glia Interactions, The Neuroscientist, 10.1177/1073858411403317, 18:3, (237-250), Online publication date: 1-Jun-2012. Constantinou S and Fern R (2009) Conduction block and glial injury induced in developing central white matter by glycine, GABA, noradrenalin, or nicotine, studied in isolated neonatal rat optic nerve, Glia, 10.1002/glia.20839, 57:11, (1168-1177), Online publication date: 15-Aug-2009. Meier S, Kafitz K and Rose C (2008) Developmental profile and mechanisms of GABA-induced calcium signaling in hippocampal astrocytes, Glia, 10.1002/glia.20684, 56:10, (1127-1137), Online publication date: 1-Aug-2008. Angulo M, Le Meur K, Kozlov A, Charpak S and Audinat E (2008) GABA, a forgotten gliotransmitter, Progress in Neurobiology, 10.1016/j.pneurobio.2008.08.002, 86:3, (297-303), Online publication date: 1-Nov-2008. Bolton S and Butt A (2005) The optic nerve: A model for axon–glial interactions, Journal of Pharmacological and Toxicological Methods, 10.1016/j.vascn.2004.08.010, 51:3, (221-233), Online publication date: 1-May-2005. Korada S and Schwartz I (1999) Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: A light and electron microscopic study, The Journal of Comparative Neurology, 10.1002/(SICI)1096-9861(19990712)409:4 3.0.CO;2-S, 409:4, (664-681), Online publication date: 12-Jul-1999. Lim C and Ho S (1998) GABAergic modulation of axonal conduction in the developing rat retinotectal pathway, Developmental Brain Research, 10.1016/S0165-3806(98)00052-2, 108:1-2, (299-302), Online publication date: 1-Jun-1998. Reece L and Lim C (1998) Onset of optic nerve conduction and synaptic potentials in superior colliculus of fetal rats studied in vitro, Developmental Brain Research, 10.1016/S0165-3806(97)00171-5, 106:1-2, (25-38), Online publication date: 1-Mar-1998. Howd A, Rattray M and Butt A (1997) Expression of GABA transporter mRNAs in the developing and adult rat optic nerve, Neuroscience Letters, 10.1016/S0304-3940(97)00699-X, 235:1-2, (98-100), Online publication date: 1-Oct-1997. This Issue22 October 1994Volume 258Issue 1351 Article InformationDOI:https://doi.org/10.1098/rspb.1994.0134PubMed:7997461Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received26/04/1994Manuscript accepted24/05/1994Published online01/01/1997Published in print22/10/1994 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad