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Amplifier‐Mediated Activation of Cell‐Penetrating Peptides with Steroids: Multifunctional Anion Transporters for Fluorogenic Cholesterol Sensing in Eggs and Blood

2008; Wiley; Volume: 48; Issue: 2 Linguagem: Inglês

10.1002/anie.200804422

1521-3773

Sara M. Butterfield, Tomohiro Miyatake, Stefan Matile,

Lipid Membrane Structure and Behavior

Off-the-shelf, prêt-à-porter multianalyte sensing systems are based on the ability of cell-penetrating peptides (CPPs; see picture, blue) to mediate the export of hydrophilic anions (yellow→green) from lipid bilayer vesicles (gray). Covalent capture of hydrophobic analytes (black) with hydrophilic anions (red) produces amphiphilic anions that can activate CPPs.