Chemie von Aziridincarbonsäuren, IV. Enantioselektive Hydratisierung von Aziridin‐2‐carbonitril
1994; Wiley; Volume: 1994; Issue: 9 Linguagem: Inglês
10.1002/jlac.199419940906
ISSN0170-2041
AutoresKlaus Jähnisch, Egon Gründemann, Annamarie Kunath, Μ. Ramm,
Tópico(s)Synthesis of β-Lactam Compounds
ResumoChemistry of Aziridinecarboxylic Acids, IV. – Enantioselective Hydration of Aziridine‐2‐carbonitrile Aziridine‐2‐carbonitrile rac ‐ 1 was hydrated enantioselectively in aqueous medium by using (2 R ,3 R ,5 R )‐(−)‐5‐(1‐hydroxy‐1‐methylethyl)‐2‐methyl‐3‐oxocyclohexanecarbonitrile (2) as chiral catalyst. The ee value of the unreacted (S)‐(−)‐aziridine‐2‐carbonitrile 1 depends on the conversion and reaches ≥99%.
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