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The autofluorescence of hyalocytes and pigment epithelium and the isolation of a fluorescing substance from these tissues

1973; Elsevier BV; Volume: 17; Issue: 4 Linguagem: Inglês

10.1016/0014-4835(73)90240-6

1096-0007

G. Cremer-Bartels, Endre A. Balazs,

Connexins and lens biology

Partially purified fractions from sheep pineal gland extracts, which show a fluorescence like pteridines, were shown to suppress the enzyme hydroxy-indole-o-methyltransferase (HIOMT) isolated from avian pineals and retinas. The results described demonstrate that the mechanism of inhibition of HIOMT activity is independent of the species and organ. A blocking effect was found in experiments whether retinal or pineal HIOMT were used and the effect was found as well with bovine HIOMT. It is shown that low molecular weight molecules show inhibitory activity and accompany the high molecular weight enzyme HIOMT.