BDNF atelocollagen mini-pellet accelerates facial nerve regeneration
1999; Elsevier BV; Volume: 849; Issue: 1-2 Linguagem: Inglês
10.1016/s0006-8993(99)02163-0
ISSN1872-6240
AutoresEiji Kohmura, Takamichi Yuguchi, Toshiki Yoshimine, T. Fujinaka, Norimasa Koseki, Akihiko Sano, Akiyoshi Kishino, Chikao Nakayama, T Sakaki, Masahiro Nonaka, Osamu Takemoto, Toru Hayakawa,
Tópico(s)Herpesvirus Infections and Treatments
ResumoWe investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration.
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