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Hydrophobically Directed Organic Synthesis

2005; Wiley; Volume: 45; Issue: 4 Linguagem: Inglês

10.1002/anie.200502882

1521-3773

Ulf M. Lindström, Фредрик Андерссон,

Chemical Reaction Mechanisms

Going with the flow: Nature has perfected the use of hydrophobic interactions in biochemical processes. Some recent work on synthesis has shown that reactions in water may be predisposed to favor transition states that optimize hydrophobic interactions (see picture). Thus, it should in principle be possible to use hydrophobic interactions as a nonbonding element of control for synthetic reactions in water.