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NEUROPEPTIDE Y IN MULTIPLE ENDOCRINE NEOPLASIA: RELEASE DURING SURGERY FOR PHAEOCHROMOCYTOMA

1987; Wiley; Volume: 26; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2265.1987.tb03641.x

1365-2265

J. M. C. Connell, Roger Corder, J. ASBURY, Stuart Macpherson, G Inglis, Philip Lowry, Alastair D. Burt, P F Semple,

Adrenal and Paraganglionic Tumors

High plasma concentrations of neuropeptide Y (NPY) were found in a patient with bilateral adrenal phaeochromocytomas and medullary thyroid carcinoma associated with MEN IIa (32 pmol/l, normal less than 3.5 pmol/l). Both adrenal tumours contained and secreted NPY. Manipulation at operation produced a remarkable increase in plasma NPY concentrations (peak = 1631 pmol/l) coinciding with increases in plasma levels of catecholamines and arterial pressure. NPY was also shown to be present in thyroid tumour tissue: the concentration of NPY in tumour was 50-fold higher (0.9 nmol/g vs 0.004 nmol/g) than in adjacent normal thyroid tissue. It is possible that NPY from some phaeochromocytomas may contribute to hypertension during surgery.