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Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naïve CD8+ T cells in the bone marrow

2013; Elsevier BV; Volume: 122; Issue: 2 Linguagem: Inglês

10.1182/blood-2012-01-401265

1528-0020

Idan Milo, Anita Sapoznikov, Vyacheslav Kalchenko, Orna Tal, Rita Krauthgamer, Nico van Rooijen, Diana Dudziak, Steffen Jung, Guy Shakhar,

Immune Response and Inflammation

Key Points Soluble blood-borne antigens are crosspresented in the BM, triggering T-cell arrest, clustering, and in situ proliferation. In the BM, not only DCs but also other mononuclear phagocytes participate in crosspresentation.