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Effects of Subthalamic Nucleus Stimulation on Urodynamic Findings in Patients with Parkinson’s Disease

2003; Lippincott Williams & Wilkins; Volume: 169; Issue: 4 Linguagem: Inglês

10.1097/01.ju.0000055520.88377.dc

1527-3792

Enrico Finazzi Agrò, Antonella Peppe, Andrea d’Amico, Filomena Petta, Paolo Mazzone, Paolo Stanzione, F Micali, Carlo Caltagirone,

Botulinum Toxin and Related Neurological Disorders

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Apr 2003Effects of Subthalamic Nucleus Stimulation on Urodynamic Findings in Patients with Parkinson's Disease ENRICO FINAZZI-AGRÒ, ANTONELLA PEPPE, ANDREA D'AMICO, FILOMENA PETTA, PAOLO MAZZONE, PAOLO STANZIONE, FRANCESCO MICALI, and CARLO CALTAGIRONE ENRICO FINAZZI-AGRÒENRICO FINAZZI-AGRÒ , ANTONELLA PEPPEANTONELLA PEPPE , ANDREA D'AMICOANDREA D'AMICO , FILOMENA PETTAFILOMENA PETTA , PAOLO MAZZONEPAOLO MAZZONE , PAOLO STANZIONEPAOLO STANZIONE , FRANCESCO MICALIFRANCESCO MICALI , and CARLO CALTAGIRONECARLO CALTAGIRONE View All Author Informationhttps://doi.org/10.1097/01.ju.0000055520.88377.dcAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Although the effects of subthalamic nucleus stimulation on the control of motor symptoms in patients with Parkinson's disease have been demonstrated, to our knowledge there are no data on effects of this treatment on voiding. We evaluated differences in urodynamic findings in patients with Parkinson's disease during on and off subthalamic nucleus stimulation status. Materials and Methods: We evaluated 3 males and 2 females with Parkinson's disease. All patients had undergone surgical bilateral implantation of subthalamic nucleus electrodes 4 to 9 months before our observation. Urodynamic evaluation was performed during chronic subthalamic nucleus stimulation and 30 minutes after turning off the stimulators. Certain parameters were evaluated, including bladder compliance and capacity, first desire to void volume, bladder volume of appearance (reflex volume) and amplitude of detrusor hyperreflexic contractions, maximum flow, detrusor pressure at maximum flow and detrusor-sphincter coordination. Results were compared statistically. Results: Statistically significant differences in urodynamic data obtained during on and off subthalamic nucleus stimulation status were noted. In particular bladder capacity and reflex volume were increased for on status (median 320 versus 130 ml., p = 0.043 and 250 versus 110, p = 0.043, respectively). The amplitude of detrusor hyperreflexic contractions was decreased for on status but the difference was not significant (median 23 versus 37 cm. H2O, p = 0.223). No differences were noted in the other urodynamic parameters considered during the filling and voiding phases. Conclusions: Our experience shows that subthalamic nucleus stimulation seems to be effective for decreasing detrusor hyperreflexia in Parkinson's disease cases. This finding confirms a role for basal ganglia in voiding control. References 1 : Voiding dysfunction in Parkinson's disease. Jpn J Psychiatry Neurol1992; 46: 181. Google Scholar 2 : Urinary disorders in Parkinson's disease and multiple system atrophy. Funct Neurol2001; 16: 277. Google Scholar 3 : Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet1977; 12: 345. 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Lucia, Rome, Italy© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByGriebling T (2018) Re: Bladder Dysfunction in Advanced Parkinson's DiseaseJournal of Urology, VOL. 189, NO. 5, (1818-1819), Online publication date: 1-May-2013. Volume 169Issue 4April 2003Page: 1388-1391 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordssubthalamic nucleusbladderurodynamicselectric stimulationParkinson diseaseMetricsAuthor Information ENRICO FINAZZI-AGRÒ More articles by this author ANTONELLA PEPPE More articles by this author ANDREA D'AMICO More articles by this author FILOMENA PETTA More articles by this author PAOLO MAZZONE More articles by this author PAOLO STANZIONE More articles by this author FRANCESCO MICALI More articles by this author CARLO CALTAGIRONE More articles by this author Expand All Advertisement PDF DownloadLoading ...