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Hydroxyapatite whisker-reinforced polyetherketoneketone bone ingrowth scaffolds

2009; Elsevier BV; Volume: 6; Issue: 3 Linguagem: Inglês

10.1016/j.actbio.2009.08.004

1878-7568

Gabriel L. Converse, Timothy L. Conrad, Christina H. Merrill, Ryan K. Roeder,

Orthopaedic implants and arthroplasty

Hydroxyapatite (HA) whisker-reinforced polyetherketoneketone (PEKK) bone ingrowth scaffolds were prepared and characterized. High levels of porosity (75–90%) and HA whisker reinforcement (0–40 vol.%) were attained using a powder processing approach to mix the HA whiskers, PEKK powder and a NaCl porogen, followed by compression molding at 350–375 °C and particle leaching to remove the porogen. The scaffold architecture and microstructure exhibited characteristics known to be favorable for osteointegration. Scaffold porosity was interconnected with a mean pore size in the range 200–300 μm as measured by micro-computed tomography. HA whiskers were embedded within and exposed on the surface of scaffold struts, producing a microscale surface topography, shown by von Kossa staining and scanning electron microscopy. Therefore, HA whisker-reinforced PEKK bone ingrowth scaffolds may be advantageous for orthopedic implant fixation, including interbody spinal fusion.