Facial Cosmetic Filler Injections as Possible Target for Systemic Sarcoidosis in Patients Treated with Interferon for Chronic Hepatitis C: Two Cases
2008; Karger Publishers; Volume: 217; Issue: 1 Linguagem: Inglês
10.1159/000128281
ISSN1421-9832
AutoresV. Descamps, Jennifer Landry, Camille Françès, Eduardo Marinho, Vlad Ratziu, O. Chosidow,
Tópico(s)Sarcoidosis and Beryllium Toxicity Research
Resumo<i>Background:</i> Cosmetic filler injections are now a very common procedure for aesthetic purposes. Today no contra-indication is given anymore to any patient for an intradermal filling. <i>Objectives:</i> We draw attention to a possible side effect of facial fillers in a population at risk. <i>Results:</i> We report 2 similar cases of systemic sarcoidosis in patients who both developed a sarcoidal granuloma at the location of a cosmetic filler injection during combined interferon and ribavirin treatment for chronic hepatitis C infection. Cosmetic fillers were hyaluronic acid for one patient and probably silicone for the other. <i>Conclusion:</i> Patients with chronic hepatitis C have a higher risk of interferon-induced sarcoidosis. Physicians must be aware of the risk that a granuloma can develop after a dermal filler injection especially in patients treated with interferon for chronic hepatitis C. These reactions may reveal a systemic sarcoidosis. We propose to perform a test for a hepatitis C virus infection before injecting a dermal filler and to inform the patient of this risk in case of a hepatitis C infection that could necessitate an interferon treatment.
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