The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class
2002; Elsevier BV; Volume: 12; Issue: 16 Linguagem: Inglês
10.1016/s0960-894x(02)00352-9
ISSN1464-3405
AutoresRichard J. Sciotti, Marina Pliushchev, Paul E. Wiedeman, Darlene Balli, Robert K. Flamm, Angela M. Nilius, Kennan Marsh, DeAnne Stolarik, Robert A. Jolly, Roger G. Ulrich, Stevan W. Djurić,
Tópico(s)Radical Photochemical Reactions
ResumoA novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
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