Suppression of voluntary ethanol consumption in rats by gamma-butyrolactone
1983; Elsevier BV; Volume: 32; Issue: 13 Linguagem: Inglês
10.1016/0024-3205(83)90913-x
ISSN1879-0631
AutoresF Fadda, Antonio Argiolas, Maria Rosaria Melis, Maria Graziella De Montis, Gian Luigi Gessa,
Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoThe effect of gamma-butyrolactone (GBL) on voluntary ethanol intake was studied in a group of Wistar rats in which a stable preference had been induced by exposure to increasing ethanol concentrations. These rats drank 60% of their daily fluid intake as 15% ethanol solution, corresponding to about 6 g ethanol/kg/day. GBL, injected intraperitoneally at the dose of 200 mg/kg, twice daily for 3 consecutive days, decreased ethanol intake by about 80% on the days of treatment, but did not reduce total fluid intake. Ethanol intake remained significantly reduced up to the 5th day following cessation of GBL administration. GBL, up to a concentration of 10−3 M, inhibited neither alcohol-dehydrogenase nor aldehyde-dehydrogenase in rat liver homogenates, nor dopamine-β-hydroxylase in homogenates of adrenal medulla or hypothalamus of rats. It is suggested that inhibition of firing in dopaminergic neurons mediates the suppressant effect of GBL on ethanol preference.
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