An abnormal reaction occurring in the presence of L-aromatic aminoacid decarboxylase
1981; Elsevier BV; Volume: 99; Issue: 2 Linguagem: Inglês
10.1016/0006-291x(81)91784-8
ISSN1090-2104
AutoresE. Barboni, Carla Borri Voltattorni, Maria D’Erme, Alessandro Fiori, Alba Minelli, Maria Anna Rosei, C Turano,
Tópico(s)Polyamine Metabolism and Applications
ResumoThe reaction of L-aromatic aminoacid decarboxylase (EC 4.1.1.28) with α-methyl-L-DOPA or 5-hydroxy-L-tryptophan leads to the formation of dihydroxyphenylacetone or, respectively, 5-hydroxyindolacetaldeyde. These are produced in amounts far exceeding, on molar basis, that of the coenzyme, pyridoxal-5′-phosphate. The reaction cannot therefore be simply a decarboxylation-dependent transamination, using the coenzyme as an amino group acceptor. Evidence is presented which rules out the possibility that this phenomenon is due to an oxidative deamination.
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