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Bladder Afferent Signaling: Recent Findings

2010; Lippincott Williams & Wilkins; Volume: 183; Issue: 4 Linguagem: Inglês

10.1016/j.juro.2009.12.060

1527-3792

Anthony Kanai, Karl‐Erik Andersson,

Urological Disorders and Treatments

No AccessJournal of UrologyReview Article1 Apr 2010Bladder Afferent Signaling: Recent Findings Anthony Kanai and Karl-Erik Andersson Anthony KanaiAnthony Kanai More articles by this author and Karl-Erik AnderssonKarl-Erik Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.12.060AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Much current research on lower urinary tract physiology focuses on afferent mechanisms. The main goals are to define and control the signaling pathways by which afferent information is generated and conveyed to the central nervous system. We summarize recent research on bladder afferent mechanisms. Materials and Methods: We systematically reviewed the literature by searching PubMed® up to June 2009 with focus on the last 5 years. Results: At least 2 signaling pathways can be identified, including the urothelial and the myogenic pathway. The urothelial pathway is a functional unit consisting of the urothelium, interstitial cells and afferent nerves in the lamina propria. Signaling occurs via muscle-mucosal mechanoreceptors, mucosal mechanoreceptors and chemoreceptors. The myogenic pathway is activated via in-series mechanoreceptors responding to distention and via spontaneous contractile activity in units of myocytes generating afferent noise. Conclusions: To control dysfunctional micturition we must know more about all components involved in normal micturition control, including how afferent information is handled by the central nervous system. References 1 : Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev2004; 84: 935. Google Scholar 2 : Mechanisms of disease: involvement of the urothelium in bladder dysfunction. Nat Clin Pract Urol2007; 4: 46. 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Link, Google Scholar Department of Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine (KEA), Winston Salem, North Carolina© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLee K, Mitsui R, Kajioka S, Naito S and Hashitani H (2016) Role of PTHrP and Sensory Nerve Peptides in Regulating Contractility of Muscularis Mucosae and Detrusor Smooth Muscle in the Guinea Pig BladderJournal of Urology, VOL. 196, NO. 4, (1287-1294), Online publication date: 1-Oct-2016.Teichman J (2014) Editorial CommentJournal of Urology, VOL. 192, NO. 6, (1685-1685), Online publication date: 1-Dec-2014.Andersson K, Martin N and Nitti V (2013) Selective β3-Adrenoceptor Agonists for the Treatment of Overactive BladderJournal of Urology, VOL. 190, NO. 4, (1173-1180), Online publication date: 1-Oct-2013.Gregorini F, Wöllner J, Schubert M, Curt A, Kessler T and Mehnert U (2012) Sensory Evoked Potentials of the Human Lower Urinary TractJournal of Urology, VOL. 189, NO. 6, (2179-2185), Online publication date: 1-Jun-2013.Brumovsky P, Seal R, Lundgren K, Seroogy K, Watanabe M and Gebhart G (2012) Expression of Vesicular Glutamate Transporters in Sensory and Autonomic Neurons Innervating the Mouse BladderJournal of Urology, VOL. 189, NO. 6, (2342-2349), Online publication date: 1-Jun-2013.Apostolidis A (2011) Novel Insights and Targets for Managing Overactive BladderJournal of Urology, VOL. 185, NO. 6, (2018-2020), Online publication date: 1-Jun-2011.Andersson K (2010) Detrusor Underactivity/Underactive Bladder: New Research Initiatives NeededJournal of Urology, VOL. 184, NO. 5, (1829-1830), Online publication date: 1-Nov-2010. Volume 183Issue 4April 2010Page: 1288-1295 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Keywordsafferent pathwaysurination disordersmuscle contractionurotheliumurinary bladderMetrics Author Information Anthony Kanai More articles by this author Karl-Erik Andersson More articles by this author Expand All Advertisement PDF downloadLoading ...