Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism
1992; Wiley; Volume: 106; Issue: 2 Linguagem: Inglês
10.1111/j.1476-5381.1992.tb14321.x
ISSN1476-5381
AutoresMalcolm P. Caulfield, David A. Brown,
Tópico(s)Ion channel regulation and function
ResumoCannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%).
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