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Immunocytochemical detection of proliferating cells in the rat tooth germ by monoclonal antibodies against 5-bromo-2′-deoxyuridine

1989; Elsevier BV; Volume: 34; Issue: 1 Linguagem: Inglês

10.1016/0003-9969(89)90047-2

1879-1506

Andrea Casasco, Alberto Calligaro, Carla Marchetti, Paola Poggi, Silvia Brugnatelli, Marco Danova, Roberto Fiocca,

Virus-based gene therapy research

5-Bromo-2′-deoxyuridine incorporated into DNA synthesizing cells in vivo is detected by a monoclonal antibody. The results are similar to those obtained with cytoautoradiography, but show variance with data from some past autoradiographic studies. This immunocytochemical technique may be a useful tool for study of cell kinetics in the oral tissues.