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Gut-Liver Interactions in the IgA System

1985; Taylor & Francis; Volume: 20; Issue: sup114 Linguagem: Inglês

10.3109/00365528509093766

1502-7708

H. J. F. Hodgson,

Gastrointestinal motility and disorders

Recent experimental work in rodents has demonstrated that the liver can function as an ‘IgA—pump’, transporting polymeric IgA from serum to bile via a secretory-component mediated uptake at the surface of the hepatic parenchymal cell. Studies are surveyed which indicate that, although this process occurs in man. it is to a strikingly lesser degree, and interruption of this pathway does not explain the high serum IgA levels often seen in chronic liver disease: the explanation for this lies in enhanced synthesis of IgA, and, diminished polymeric IgA catabolism unrelated to hepatobiliary transport.