Effect of T-2 mycotoxin on rat liver mitochondria electron transport system
1983; Elsevier BV; Volume: 21; Issue: 5 Linguagem: Inglês
10.1016/0041-0101(83)90273-8
ISSN1879-3150
Autores Tópico(s)Nicotinic Acetylcholine Receptors Study
ResumoThe in vitro and in vivo effects of T-2 mycotoxin on electron transport in rat liver mitochondria were investigated. T-2 toxin (2.2 mM) inhibited oxygen consumption by 40% in ADP-coupled and DNP-uncoupled mitochondria using either succinate or pyridine-nucleotide linked substrates. Studies employing known inhibitors of specific sites along the electron transport chain identified site I as the principal site of action of T-2 toxin. In vivo experiments using an LD50 dose of T-2 toxin showed early (10 hr) decreases in succinate and pyruvate plus malate oxidation in liver mitochondria. This observation is supported by in vitro findings and suggests that mitochondria are a possible site of T-2 action.
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