Significance of a prothrombin assay method using echis carinatus venom for diagnostic information in disseminated intravascular coagulation syndrome
1975; Elsevier BV; Volume: 7; Issue: 4 Linguagem: Inglês
10.1016/0049-3848(75)90110-3
ISSN1879-2472
AutoresN Sakuragawa, Kaoru Takahashi, Mari Hoshiyama, Chozo Jimbo, Matsuzo Matsuoka, Yoshihisa Onishi,
Tópico(s)Venous Thromboembolism Diagnosis and Management
ResumoPrethrombin 1 was found in the blood of patients who have the disseminated intravascular coagulation syndrome (DIC). Prothrombin assay method using venom is useful for detecting prothrombin derivatives such as prethrombin 1 (1) in DIC. This prethrombin is produced from prothrombin by the proteolytic effect of thrombin and is difficult to convert to thrombin by physiologic procoagulants. This fact is demonstrated by a bioassay of the interaction between purified prothrombin and purified thrombin and is shown by means of SDS-disc electrophoresis in this paper. Detection of the discrepancy of prothrombin values obtained by methods using thrombøplastin as compared with venom is useful for diagnøsing DIC, and also for the differentiation of DIC from primary fibrinolysis.
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