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Nasal Lymphomas in Japan: A High Prevalence of Epstein-Barr Virus Type A and Deletion Within the Latent Membrane Protein Gene

1999; Taylor & Francis; Volume: 35; Issue: 5-6 Linguagem: Inglês

10.1080/10428199909169621

1042-8194

Junji Suzumiya, Koichi Ohshima, Morishige Takeshita, Motonobu Kanda, Chika Kawasaki, Nobuhiro Kimura, Kazuo Tamura, Masahiro Kikuchi,

Immune Cell Function and Interaction

The majority of nasal lymphomas are of the natural killer (NK)/T cell lineage. We analyzed 33 specimens of nasal lymphoma from Japanese patients for Epstein-Barr virus (EBV). Phenotypic and genetic analyses showed 28 cases with NK/T cell type and 5 cases with B cell type. All NK/T lymphomas were of pleomorphic cell type except 2 large cell (centroblastoid) and one lymphoblastic lymphoma. All cases with nasal B cell lymphoma were of large (centroblastoid) cell type. EBV was detected in all cases of NK/T cell type with the exception of one lymphoblastic case, and was monoclonally integrated in all cases examined (14/14 cases). All but one case had subtype A of EBV infection with 30-base paired deleted LMP-1 gene. One case of B cell lymphoma showed the presence of EBV infection with subtype A and deletion of LMP-1. Our results indicate that the majority of nasal lymphomas in Japanese patients are of the nasal NK/T cell type, have pleomorphic morphology, a high prevalence of EBV with a monoclonal integration, subtype A and deleted LMP-1 gene. In contrast, nasal B cell lymphoma showed monomorphic appearance and rare EBV infection.