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Isotretinoin and Staphylococcus aureus Infection

1986; American Medical Association; Volume: 122; Issue: 7 Linguagem: Inglês

10.1001/archderm.1986.01660190093024

1538-3652

Mark L. Graham,

Ocular Infections and Treatments

† The use of isotretinoin (13- cis -retinoic acid) in the treatment of numerous dermatologic disorders, as well as the side effects encountered with use of the drug, have increased remarkably since its release. We encountered a case of Staphylococcus aureus endocarditis in a patient with chronic stable aortic insufficiency undergoing therapy with isotretinoin for extensive actinic keratoses. Although significant dysfunction of the immune system has not been demonstrated with isotretinoin, nasal colonization with S aureus has been shown to occur. Changes in skin fragility caused by the drug may provide a portal of entry for the organism. Physicians should be alert for this potential complication in patients with an underlying cardiac valvular lesion; antibiotic prophylaxis may be indicated in this group during isotretinoin therapy. ( Arch Dermatol 1986;122:815-817)