IS GENETIC AMNIOCENTESIS WARRANTED WHEN ISOLATED CHOROID PLEXUS CYSTS ARE FOUND?
1996; Wiley; Volume: 16; Issue: 11 Linguagem: Inglês
10.1002/(sici)1097-0223(199611)16
ISSN1097-0223
AutoresDiana L. Gray, Renee C. Winborn, TERESA L. SUESSEN, James P. Crane,
Tópico(s)Pregnancy and preeclampsia studies
ResumoPrenatal DiagnosisVolume 16, Issue 11 p. 983-990 Original Paper IS GENETIC AMNIOCENTESIS WARRANTED WHEN ISOLATED CHOROID PLEXUS CYSTS ARE FOUND? DIANA L. GRAY, Corresponding Author DIANA L. GRAY Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Diana L. Gray, MD, Department of Obstetrics and Gynecology, The Jewish Hospital of St Louis, 216 S. Kingshighway, St Louis, MO 63110, U.S.A.Search for more papers by this authorRENEE C. WINBORN, RENEE C. WINBORN Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this authorTERESA L. SUESSEN, TERESA L. SUESSEN Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this authorJAMES P. CRANE, JAMES P. CRANE Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this author DIANA L. GRAY, Corresponding Author DIANA L. GRAY Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Diana L. Gray, MD, Department of Obstetrics and Gynecology, The Jewish Hospital of St Louis, 216 S. Kingshighway, St Louis, MO 63110, U.S.A.Search for more papers by this authorRENEE C. WINBORN, RENEE C. WINBORN Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this authorTERESA L. SUESSEN, TERESA L. SUESSEN Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this authorJAMES P. CRANE, JAMES P. CRANE Division of Genetics and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, U.S.A.Search for more papers by this author First published: November 1996 https://doi.org/10.1002/(SICI)1097-0223(199611)16:11 3.0.CO;2-CCitations: 25AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Our aim was to evaluate the prevalence of trisomy 18 in the setting of isolated fetal choroid plexus cysts and then to consider the risk of trisomy 18 versus the risks of genetic amniocentesis. Fetuses with choroid plexus cysts were prospectively obtained from a total mid-trimester population of 18 861 fetuses with known outcomes. If the fetuses had trisomy 18, they were part of the study group and part of the control group if they had normal karyotypes. Scans were retrospectively reviewed for the characterization of cysts according to size, laterality, and appearance (simple or complex echo patterns). Chi-square analysis of contingency tables of results was performed. 208/18 861 (1·1 per cent) fetuses had choroid plexus cysts. 201/208 (96·6 per cent) were normal fetuses or newborns, while 7/208 (3·4 per cent) of the fetuses with choroid plexus cysts had trisomy 18. Overall, 16 fetuses had trisomy 18 and seven (44 per cent) of these had choroid plexus cysts. 0/16 fetuses had choroid plexus cysts as the only sonographic finding. Although laterality or complexity of the cysts did not correlate with the presence or absence of a cytogenetic abnormality, cysts ⩾10 mm were more often associated with trisomy 18 than with a normal karyotype (P<0·01). We conclude that the discovery of choroid plexus cysts in otherwise normal fetuses in the late second trimester does not by itself justify the risks of genetic amniocentesis. References Benacerraf, B. R., Laboda, L. A. (1989). Cyst of the fetal choroid plexus: a normal variant?, Am. J. Obstet. Gynecol., 160, 319–321. Benacerraf, B. R., Harlow, B., Frigoletto, F. D. (1990). Are choroid plexus cysts an indication for second- trimester amniocentesis?, Am. J. Obstet. Gynecol., 162, 1001–1006. Bundy, A. L., Saltzman, D. H., Pober, B., Fine, C., Emerson, D., Doubilet, P. M. (1986). Antenatal sonographic findings in trisomy 18, J. Ultrasound Med., 5, 361–364. Canick, J. A., Palomaki, G. E., Osathanondh, R. (1990). Prenatal screening for trisomy 18 in the second trimester, Prenat. Diagn., 10, 546–548. Chan, L., Hixson, J. L., Laifer, S. A., Marchese, S. G., Martin, J. G., Hill, L. M. (1989). A sonographic and karyotypic study of second-trimester fetal choroid plexus cysts, Obstet. Gynecol., 73, 703–706. Chitkara, U., Cogswell, C., Norton, K., Wilkins, I. A., Mehalek, K., Berkowitz, R. L. (1988). Choroid plexus cysts in the fetus: a benign anatomic variant or pathologic entity? Report of 41 cases and review of the literature, Obstet. Gynecol., 72, 815–819. Chudleigh, P., Pearce, J. M., Campbell, S. (1984). The prenatal diagnosis of transient cysts of the fetal choroid plexus, Prenat. Diagn., 4, 135–137. Clark, S. L., DeVore, G. R., Sabey, P. L. (1988). Prenatal diagnosis of cysts of the fetal choroid plexus, Obstet. Gynecol., 72, 585–587. Crandall, B. F., Howard, J., Lebherz, T. B., Rubinstein, L., Sample, W. F., Sarti, D. (1980). Follow-up of 2000 second-trimester amniocenteses, Obstet. Gynecol., 56, 625–628. DeRoo, T. R., Harris, R. D., Sargent, S. K., Denholm, T. A., Crow, H. C. (1988). Fetal choroid plexus cysts: prevalence, clinical significance, and sonographic appearance, Am. J. Roentgenol., 51, 1179–1181. Farhood, A. I., Morris, J. H., Bieber, F. R. (1987). Transient cysts of the fetal choroid plexus: morphology and histogenesis, Am. J. Med. Genet., 27, 977–982. Fitzsimmons, J., Wilson, D., Pascoe-Mason, J., Shaw, C. M., Cyr, D. R., Mack, L. A. (1989). Choroid plexus cysts in fetuses with trisomy 18, Obstet. Gynecol., 73, 257–260. Gross, S. J., Shulman, L. P., Tolley, E. A., et al. (1985). Isolated fetal choroid plexus cysts and trisomy 18: review and meta-analysis, Am. J. Obstet. Gynecol., 172, 83–87. Kupferminc, M. J., Tamura, R. K., Sabbagha, R. E., Parilla, B. V., Cohen, L. S., Pergament, E. (1994). Isolated choroid plexus cyst(s): an indication for amniocentesis, Am. J. Obstet. Gynecol., 171, 1068–1071. Nadel, A. S., Bromley, B. S., Frigoletto, F. D., Estroff, J. A., Benacerraf, B. R. (1992). Isolated choroid plexus cysts in the second-trimester fetus: is amniocentesis really indicated?, Radiology, 185, 545–548. Nicolaides, K. H., Rodeck, C. H., Gosden, C. M. (1986). Rapid karyotyping in non-lethal fetal malformations, Lancet, 283–287. Ostlere, S. J., Irving, H. C., Lilford, R. J. (1990). Fetal choroid plexus cysts a report of 100 cases, Radiology, 175, 753–755. Snijders, R. J. M., Shawa, L., Nicolaides, K. H. (1994). Fetal choroid plexus cysts and trisomy 18: assessment of risk based on ultrasound findings and maternal age, Prenat. Diagn., 14, 1119–1127. Walkinshaw, S., Pilling, D., Spriggs, A. (1994). Isolated choroid plexus cysts–the need for routine offer of karyotyping, Prenat. Diagn., 14, 663–667. Citing Literature Volume16, Issue11November 1996Pages 983-990 ReferencesRelatedInformation
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