Self-assembled, thermoresponsive micelles based on triblock PMMA- b -PNIPAAm- b -PMMA copolymer for drug delivery
2007; IOP Publishing; Volume: 18; Issue: 21 Linguagem: Inglês
10.1088/0957-4484/18/21/215605
ISSN1361-6528
AutoresY Y Li, Xuan Zhang, Jingling Zhu, Han Cheng, Si‐Xue Cheng, R.‐X. Zhuo,
Tópico(s)Advanced Polymer Synthesis and Characterization
ResumoA novel thermosensitive amphiphilic ABA triblock poly(methyl methacrylate)-b-poly(N-isopropylacrylamide)-b-poly(methyl methacrylate) copolymer (PMMA-b-PNIPAAm-b-PMMA) comprised of two hydrophobic PMMA segments and one hydrophilic PNIPAAm segment was designed and synthesized. The structure of the copolymer was characterized by FT-IR, 1HNMR, and GPC analysis. The cytotoxicity study showed that the PMMA-b-PNIPAAm-b-PMMA copolymer exhibited low cytotoxicity. The copolymer was capable of self-assembling into micelles in water and demonstrated temperature sensitivity at around 34.5 °C. Transmission electron microscopy (TEM) showed that the micelles exhibit nanosized spherical morphology within a size range of 60 nm with a critical micellar concentration (CMC) at 10 mg l−1. The drug-loading PMMA-b-PNIPAAm-b-PMMA micelles showed thermosensitive-controlled release which indicates the potential of PMMA-b-PNIPAAm-b-PMMA micelles as drug carriers.
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