Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus.
1987; Springer Nature; Volume: 40; Issue: 1 Linguagem: Inglês
10.7164/antibiotics.40.1
ISSN1881-1469
AutoresIO Kibwage, Gerard Janssen, Roger Busson, Jos Hoogmartens, H. Vanderhaeghe, L. Verbist,
Tópico(s)Mycobacterium research and diagnosis
ResumoThe identification of five novel compounds, pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-N-demethylery thromycin A-6, 9-hemiketal, 5-O-β-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13→C11 trans-lactonization. The five compounds have very little antimicrobial activity.
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