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Shock‐Like Sensations During Venlafaxine Withdrawal

2003; Wiley; Volume: 23; Issue: 5 Linguagem: Inglês

10.1592/phco.23.5.678.32198

1875-9114

Roy R. Reeves, James E Mack, John J Beddingfield,

Electroconvulsive Therapy Studies

Electric shock‐like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock‐like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.