Immunological studies on Egyptian cobra antivenin
1973; Elsevier BV; Volume: 11; Issue: 1 Linguagem: Inglês
10.1016/0041-0101(73)90148-7
ISSN1879-3150
AutoresA.H. Mohamed, Medhat A. Darwish, M. Hani-Ayobe,
Tópico(s)Rabies epidemiology and control
ResumoAbstract A monovalent specific antivenin was prepared in horses against the Egyptian cobra (Naje haje) venom; using bentonite as an adjuvant. One ml of the serum tested at the end of the six-month program neutralized 64 ld 50 and protected against 53 ld 50 in mice. Cross immunological studies were carried out with five elapid, six viperid and one crotalid venoms. The serum proved effective in neutralization of and protection against these venoms. Precipitation reaction lines were obtained using the Ouchterlony technique, with most of the venoms. Identity patterns were established between venoms of N. haje, N. nigricollis, N. flava, N. naja, Walterinnesia aegyptia of the Elapidae as well as those of Echis carinatus and Ethiopian N. haje. Partial identity with the two vipers Cerastes cerastes and Cerastes vipera and nonidentity with Echis coloratus venom. Weak or no reactions were given with the Ethiopian Bitis lachesis, Bitis gabonica and the Japanese Trimeresurus flavoviridis.
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