Portal de Periódicos da CAPES

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton

2006; Nature Portfolio; Volume: 7; Issue: 10 Linguagem: Inglês

10.1038/nrm2003

1471-0080

Yonatan B. Tzur, Katherine L. Wilson, Yosef Gruenbaum,

Virus-based gene therapy research

The SUN-domain family of nuclear envelope proteins interacts with KASH-domain proteins, which are also nuclear envelope proteins, to form 'bridges' across the inner and outer nuclear membranes. SUN-domain proteins are now proposed to provide a mechanical connection between the nucleoskeleton and the cytoskeleton. The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.