Portal de Periódicos da CAPES

INTERLEUKIN-10 LEVELS IN SEMINAL PLASMA: IMPLICATIONS FOR CHRONIC PROSTATITIS-CHRONIC PELVIC PAIN SYNDROME

2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 2 Part 1 Linguagem: Inglês

10.1016/s0022-5347(01)69139-0

1527-3792

Lauri Miller, KATERI A. FISCHER, S. Goralnick, Mark D. Litt, Joseph A. Burleson, Peter C. Albertsen, Donald L. Kreutzer,

Pelvic floor disorders treatments

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2002INTERLEUKIN-10 LEVELS IN SEMINAL PLASMA: IMPLICATIONS FOR CHRONIC PROSTATITIS-CHRONIC PELVIC PAIN SYNDROME LAURI J. MILLER, KATERI A. FISCHER, SANDRA J. GORALNICK, MARK LITT, JOSEPH A. BURLESON, PETER ALBERTSEN, and DONALD L. KREUTZER LAURI J. MILLERLAURI J. MILLER More articles by this author , KATERI A. FISCHERKATERI A. FISCHER More articles by this author , SANDRA J. GORALNICKSANDRA J. GORALNICK More articles by this author , MARK LITTMARK LITT More articles by this author , JOSEPH A. BURLESONJOSEPH A. BURLESON More articles by this author , PETER ALBERTSENPETER ALBERTSEN More articles by this author , and DONALD L. KREUTZERDONALD L. KREUTZER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69139-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-γ and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment. Materials and Methods: We measured levels of IL-8, interferon-γ, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score. Results: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-γ, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p <0.01) and pain severity (r = 0.53, p <0 0.01), and inversely with spousal support (r = −0.39, p <0.04). Conclusions: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome. References 1 : How common is prostatitis? A national survey of physician visits. J Urol1998; 159: 1224. Link, Google Scholar 2 Long-Range Plan Window in the 21st Century. National Kidney and Urologic Diseases Advisory Board. Bethesda, Maryland: United States Department of Health and Human Services, National Institutes of Health and Human Services, National Institutes of Health1990: 20. Google Scholar 3 : Chronic prostatitis: a thorough search for etiologically involved microorganisms in 1,461 patients. Infection1991; 19: S119. Crossref, Medline, Google Scholar 4 : Prostatitis: evolving management strategies. Urol Clin North Am1999; 26: 737. Crossref, Medline, Google Scholar 5 : Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology1998; 52: 744. Crossref, Medline, Google Scholar 6 : Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology1999; 54: 229. Crossref, Medline, Google Scholar 7 : The role of tumor necrosis factor and interleukin 1 in the immunoinflammatory response. Pharmacol Res1988; 5: 129. Crossref, Google Scholar 8 : IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis. J Urol2000; 164: 214. Link, Google Scholar 9 : IL-1ra versus IL-1 levels in prostatic fluid from prostatitis patients. Urol Int1998; 60: 92. Crossref, Medline, Google Scholar 10 : The West-Haven Yale Multidimensional Pain Inventory (WHYMPI). Pain1985; 23: 345. Crossref, Medline, Google Scholar 11 : The McGill Pain Questionnaire: major properties and scoring methods. Pain1975; 1: 277. Crossref, Medline, Google Scholar 12 : The American Urological Association symptom index for benign prostatic hyperplasia. Measurement Committee of the American Urological Association J Urol1992; 148: 1549. Abstract, Google Scholar 13 : National Institute of Health-National Institute of Diabetes and Digestive and Kidney Diseases Workshop on Chronic Prostatitis. Executive Summary. Bethesda, Maryland: United States Department of Health and Human ServicesDecember 1995. Google Scholar 14 : Interleukin-10: biology, role in inflammation and autoimmunity. Ann Allergy Asthma Immunol1997; 79: 469. Crossref, Medline, Google Scholar 15 : Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med1989; 170: 2081. Crossref, Medline, Google Scholar 16 : Serum levels of IL-10, IL-6, IL-1ra, and sIL-2R in patients with psoriatic arthritis. Rheumatol Int2000; 19: 101. Crossref, Medline, Google Scholar 17 : Favorable role of interleukin 10 in patients with polymyalgia rheumatica. J Rheumatol1999; 26: 1318. Medline, Google Scholar 18 : The role of spouse reinforcement, perceived pain, and activity levels of chronic pain patients. J Psychosom Res1987; 31: 251. Crossref, Medline, Google Scholar 19 : Pain-relevant support as a buffer from depression among chronic pain patients low in instrumental activity. Clin J Pain1993; 9: 34. Crossref, Medline, Google Scholar 20 : Spouse-assisted coping skills training in the management of knee pain in osteoarthritis: long-term followup results. Arthritis Care Res1999; 12: 101. Crossref, Medline, Google Scholar 21 : The role of marital interaction in chronic pain and depressive symptom severity. J Psychosom Res1990; 34: 401. Crossref, Medline, Google Scholar 22 : Chronic pain patient-spouse behavioral interactions predict patient disability. Pain1995; 63: 353. Crossref, Medline, Google Scholar 23 : Relative contributions of spousal support and illness appraisals to depressed mood in arthritis patients. Arthritis Care Res1995; 8: 80. Crossref, Medline, Google Scholar From the Departments of Pathology, Surgery, Behavior Science Community Health and Community Medicine and Healthcare, University of Connecticut, School of Medicine, Farmington, Connecticut© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by Moryousef J, Blankstein U, Curtis Nickel J, Krakowsky Y, Gilron I and Jarvi K (2021) Overview of seminal fluid biomarkers for the evaluation of chronic prostatitis: a scoping reviewProstate Cancer and Prostatic Diseases, 10.1038/s41391-021-00472-8, VOL. 25, NO. 4, (627-640), Online publication date: 1-Dec-2022. Chen P, Cheng J, Wu Z and Chuang Y (2022) New Frontiers of Extracorporeal Shock Wave Medicine in Urology from Bench to Clinical StudiesBiomedicines, 10.3390/biomedicines10030675, VOL. 10, NO. 3, (675) Salehi B, Butnariu M, Corneanu M, Sarac I, Vlaisavljevic S, Kitic D, Rahavian A, Abedi A, Karkan M, Bhatt I, Jantwal A, Sharifi‐Rad J, Rodrigues C, Martorell M and Martins N (2019) Chronic pelvic pain syndrome: Highlighting medicinal plants toward biomolecules discovery for upcoming drugs formulationPhytotherapy Research, 10.1002/ptr.6576, VOL. 34, NO. 4, (769-787), Online publication date: 1-Apr-2020. Chen Y, Guo K, Nagy T and Guo T (2020) Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responsesFood & Function, 10.1039/C9FO01740B, VOL. 11, NO. 1, (153-162) Heidari Z, Moudi B, Mahmoudzadeh-Sagheb H and Moudi M (2017) The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian populationHead & Face Medicine, 10.1186/s13005-017-0148-y, VOL. 13, NO. 1, Online publication date: 1-Dec-2017. Zhang L, Zhu J, Sun M, Song Y, Rahman K, Peng C, Zhang M, Ye Y and Zhang H (2017) Anti-inflammatory effect of Man-Pen-Fang, a Chinese herbal compound, on chronic pelvic inflammation in ratsJournal of Ethnopharmacology, 10.1016/j.jep.2017.06.034, VOL. 208, (57-65), Online publication date: 1-Aug-2017. Cai T, Verze P, La Rocca R, Palmieri A, Tiscione D, Luciani L, Mazzoli S, Mirone V and Malossini G (2017) The Clinical Efficacy of Pollen Extract and Vitamins on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Is Linked to a Decrease in the Pro-Inflammatory Cytokine Interleukin-8The World Journal of Men's Health, 10.5534/wjmh.2017.35.2.120, VOL. 35, NO. 2, (120), . Barranco I, Rubér M, Perez-Patiño C, Atikuzzaman M, Martinez E, Roca J and Rodriguez-Martinez H (2015) The Seminal Plasma of the Boar is Rich in Cytokines, with Significant Individual and Intra-Ejaculate VariationAmerican Journal of Reproductive Immunology, 10.1111/aji.12432, VOL. 74, NO. 6, (523-532), Online publication date: 1-Dec-2015. Hedger M (2015) The Immunophysiology of Male Reproduction Knobil and Neill's Physiology of Reproduction, 10.1016/B978-0-12-397175-3.00019-3, (805-892), . Lei Y, Ren X, Chen J, Liu D and Ruan J (2014) Protective effects of grape seed-derived procyanidin extract against carrageenan-induced abacterial prostatitis in ratsJournal of Functional Foods, 10.1016/j.jff.2014.01.016, VOL. 7, (416-424), Online publication date: 1-Mar-2014. Hakimi H, Akhondi M, Sadeghi M, Chamani L, Arababadi M, Ahmadabadi B, Hassanshahi G and Fathollahi M (2013) Seminal Levels of IL-10, IL-12, and IL-17 in Men with Asymptomatic Chlamydia InfectionInflammation, 10.1007/s10753-013-9719-7, VOL. 37, NO. 1, (122-126), Online publication date: 1-Feb-2014. Walker A, Kavelaars A, Heijnen C, Dantzer R and Daws L (2013) Neuroinflammation and Comorbidity of Pain and DepressionPharmacological Reviews, 10.1124/pr.113.008144, VOL. 66, NO. 1, (80-101), Online publication date: 1-Jan-2014. Lundh D, Hedelin H, Jonsson K, Gifford M and Larsson D (2013) Assessing chronic pelvic pain syndrome patients: Blood plasma factors and cortisol salivaScandinavian Journal of Urology, 10.3109/21681805.2013.769460, VOL. 47, NO. 6, (521-528), Online publication date: 1-Dec-2013. Cangussú S, Souza C, Castro M, Vieira L, Cunha F, Afonso L and Arantes R (2013) The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholdsExperimental Parasitology, 10.1016/j.exppara.2012.11.015, VOL. 133, NO. 2, (193-200), Online publication date: 1-Feb-2013. Chung H (2013) Chronic Prostatitis/Chronic Pelvic Pain Syndrome: What Are the Starting and Worsening Factors?The Korean Journal of Urogenital Tract Infection and Inflammation, 10.14777/kjutii.2013.8.1.7, VOL. 8, NO. 1, (7), . Wei X, Zhang G, Yuan H, Ding X, Li S, Zhang X and Hou J (2010) Detection and Quantitation of Soluble B7-H3 in Expressed Prostatic Secretions: A Novel Marker in Patients With Chronic ProstatitisJournal of Urology, VOL. 185, NO. 2, (532-537), Online publication date: 1-Feb-2011. Adorini L, Maggi M and Gacci M (2010) Immunological aspects of male accessory gland infection Clinical Andrology, 10.3109/9781841847474-36, (317-323), Online publication date: 3-Jun-2010. He L, Wang Y, Long Z and Jiang C (2010) Clinical Significance of IL-2, IL-10, and TNF-α in Prostatic Secretion of Patients With Chronic ProstatitisUrology, 10.1016/j.urology.2009.09.061, VOL. 75, NO. 3, (654-657), Online publication date: 1-Mar-2010. Hedger M (2010) Immunology of the Testis and Male Reproductive Tract Comprehensive Toxicology, 10.1016/B978-0-08-046884-6.01112-X, (189-230), . Dellabella M, Milanese G, Sigala S, d’Anzeo G, Arrighi N, Bodei S and Muzzonigro G (2009) The role of the prostatic stroma in chronic prostatitis/chronic pelvic pain syndromeInflammation Research, 10.1007/s00011-009-0086-7, VOL. 58, NO. 12, (829-836), Online publication date: 1-Dec-2009. Reyes-Gibby C, Spitz M, Yennurajalingam S, Swartz M, Gu J, Wu X, Bruera E and Shete S (2009) Role of Inflammation Gene Polymorphisms on Pain Severity in Lung Cancer PatientsCancer Epidemiology, Biomarkers & Prevention, 10.1158/1055-9965.EPI-09-0426, VOL. 18, NO. 10, (2636-2642), Online publication date: 1-Oct-2009. Zhao W, Zhang Z, Li X, Yu D, Rui X, Li G and Ding G (2009) Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA)Brazilian Journal of Medical and Biological Research, 10.1590/S0100-879X2009005000021, VOL. 42, NO. 10, (963-967) Ellem S, Wang H, Poutanen M and Risbridger G (2009) Increased Endogenous Estrogen Synthesis Leads to the Sequential Induction of Prostatic Inflammation (Prostatitis) and Prostatic Pre-MalignancyThe American Journal of Pathology, 10.2353/ajpath.2009.081107, VOL. 175, NO. 3, (1187-1199), Online publication date: 1-Sep-2009. Ochsenkühn R, Toth B, Nieschlag E, Artman E, Friese K and Thaler C (2008) Seminal plasma stimulates cytokine production in endometrial epithelial cell cultures independently of the presence of leucocytesAndrologia, 10.1111/j.1439-0272.2008.00870.x, VOL. 40, NO. 6, (364-369), Online publication date: 1-Dec-2008. Pontari M and Ruggieri M (2018) Mechanisms in Prostatitis/Chronic Pelvic Pain SyndromeJournal of Urology, VOL. 179, NO. 5S, (S61-S67), Online publication date: 1-May-2008. Le Tortorec A, Le Grand R, Denis H, Satie A, Mannioui K, Roques P, Maillard A, Daniels S, Jégou B, Dejucq-Rainsford N and Sommer P (2008) Infection of Semen-Producing Organs by SIV during the Acute and Chronic Stages of the DiseasePLoS ONE, 10.1371/journal.pone.0001792, VOL. 3, NO. 3, (e1792) Weidner W and Anderson R (2008) Evaluation of acute and chronic bacterial prostatitis and diagnostic management of chronic prostatitis/chronic pelvic pain syndrome with special reference to infection/inflammationInternational Journal of Antimicrobial Agents, 10.1016/j.ijantimicag.2007.07.044, VOL. 31, (91-95), Online publication date: 1-Feb-2008. Chen J, Zhao H and Xu Z (2018) The Prostate has Secretory Dysfunction for Category IIIA and IIIB ProstatitisJournal of Urology, VOL. 177, NO. 6, (2166-2169), Online publication date: 1-Jun-2007. Vykhovanets E, Resnick M, MacLennan G and Gupta S (2007) Experimental rodent models of prostatitis: limitations and potentialProstate Cancer and Prostatic Diseases, 10.1038/sj.pcan.4500930, VOL. 10, NO. 1, (15-29), Online publication date: 1-Mar-2007. Penna G, Mondaini N, Amuchastegui S, Degli Innocenti S, Carini M, Giubilei G, Fibbi B, Colli E, Maggi M and Adorini L (2007) Seminal Plasma Cytokines and Chemokines in Prostate Inflammation: Interleukin 8 as a Predictive Biomarker in Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Benign Prostatic HyperplasiaEuropean Urology, 10.1016/j.eururo.2006.07.016, VOL. 51, NO. 2, (524-533), Online publication date: 1-Feb-2007. Pavone-Macaluso M (2007) Chronic Prostatitis Syndrome: A Common, but Poorly Understood Condition. Part IEAU-EBU Update Series, 10.1016/j.eeus.2006.10.002, VOL. 5, NO. 1, (1-15), Online publication date: 1-Feb-2007. Takeyama K, Mitsuzawa H, Nishitani C, Shimizu T, Sano H, Kunishima Y, Takahashi S, Hotta H, Matsukawa M, Shibata K, Tsukamoto T and Kuroki Y (2007) The 6-Fluoro-8-Methoxy Quinolone Gatifloxacin Down-Regulates Interleukin-8 Production in Prostate Cell Line PC-3Antimicrobial Agents and Chemotherapy, 10.1128/AAC.00395-06, VOL. 51, NO. 1, (162-168), Online publication date: 1-Jan-2007. Schaeffer A, Anderson R, Krieger J, Lobel B, Naber K, Nakagawa M, Nickel J, Nyberg L and Weidner W Évaluation et prise en charge des syndromes douloureux pelviens chez l’homme, incluant les prostatites Les infections urinaires, 10.1007/978-2-287-48617-3_10, (141-194) Ochsenkühn R, O’Connor A, Hirst J, Gordon Baker H, de Kretser D and Hedger M (2006) The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: Influence of sperm autoimmunity and seminal leukocytesJournal of Reproductive Immunology, 10.1016/j.jri.2006.01.002, VOL. 71, NO. 1, (57-74), Online publication date: 1-Aug-2006. KHADRA A, FLETCHER P, LUZZI G, SHATTOCK R and HAY P (2006) Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritisBJU International, 10.1111/j.1464-410X.2006.06133.x, VOL. 97, NO. 5, (1043-1046), Online publication date: 1-May-2006. Engeler D, John H and Maake C (2006) Prostatitis and male factor infertility: A review of the literatureCurrent Prostate Reports, 10.1007/s11918-006-0021-0, VOL. 4, NO. 1, (45-53), Online publication date: 1-Mar-2006. Reddy B, Gonzalez R and Te A (2005) The implications of cytokines in chronic prostatitis and chronic pelvic pain syndromeCurrent Prostate Reports, 10.1007/s11918-005-0014-4, VOL. 3, NO. 4, (189-194), Online publication date: 1-Dec-2005. Untergasser G, Plas E, Pfister G, Heinrich E and Berger P (2005) Interferon-γ induces neuroendocrine-like differentiation of human prostate basal-epithelial cellsThe Prostate, 10.1002/pros.20261, VOL. 64, NO. 4, (419-429), Online publication date: 1-Sep-2005. PONTARI M and RUGGIERI M (2018) MECHANISMS IN PROSTATITIS/CHRONIC PELVIC PAIN SYNDROMEJournal of Urology, VOL. 172, NO. 3, (839-845), Online publication date: 1-Sep-2004. Keay S, Zhang C, Chai T, Warren J, Koch K, Grkovic D, Colville H and Alexander R (2004) Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndromeUrology, 10.1016/j.urology.2003.08.024, VOL. 63, NO. 1, (22-26), Online publication date: 1-Jan-2004. Khastgir J and Dickinson A (2003) Where do we stand with chronic prostatitis? An updateHospital Medicine, 10.12968/hosp.2003.64.12.2366, VOL. 64, NO. 12, (732-736), Online publication date: 1-Dec-2003. Saint F, Kurth N, Maille P, Vordos D, Hoznek A, Soyeux P, Patard J, Abbou C and Chopin D (2003) Urinary IL-2 assay for monitoring intravesical bacillus Calmette-Guérin response of superficial bladder cancer during induction course and maintenance therapyInternational Journal of Cancer, 10.1002/ijc.11352, VOL. 107, NO. 3, (434-440), Online publication date: 10-Nov-2003. Hochreiter W (2009) Male accessory gland infection: standardization of inflammatory parameters including cytokinesAndrologia, 10.1111/j.1439-0272.2003.tb00861.x, VOL. 35, NO. 5, (300-303), Online publication date: 1-Oct-2003. Maake C and John H (2003) Prostatitis versus pelvic pain syndrome: Immunologic studiesCurrent Prostate Reports, 10.1007/s11918-003-0014-1, VOL. 1, NO. 2, (95-102), Online publication date: 1-Oct-2003. Maake C and John H (2003) Prostatitis versus pelvic pain syndrome: Immunologic studiesCurrent Urology Reports, 10.1007/s11934-003-0094-z, VOL. 4, NO. 4, (327-334), Online publication date: 1-Jul-2003. Tu H, Juelich T, Smith E, Tyring S, Rady P and Hughes T (2003) Evidence for endogenous interleukin-10 during nociceptionJournal of Neuroimmunology, 10.1016/S0165-5728(03)00126-7, VOL. 139, NO. 1-2, (145-149), Online publication date: 1-Jun-2003. Richard G, Batstone D and Doble A (2003) Chronic prostatitisCurrent Opinion in Urology, 10.1097/00042307-200301000-00005, VOL. 13, NO. 1, (23-29), Online publication date: 1-Jan-2003. Miller L, Fischer K, Goralnick S, Litt M, Burleson J, Albertsen P and Kreutzer D (2002) Nerve growth factor and chronic prostatitis/chronic pelvic pain syndromeUrology, 10.1016/S0090-4295(01)01597-7, VOL. 59, NO. 4, (603-608), Online publication date: 1-Apr-2002. Volume 167Issue 2 Part 1February 2002Page: 753-756 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsprostateinterleukin-10cytokinessemenpelvic painMetrics Author Information LAURI J. MILLER More articles by this author KATERI A. FISCHER More articles by this author SANDRA J. GORALNICK More articles by this author MARK LITT More articles by this author JOSEPH A. BURLESON More articles by this author PETER ALBERTSEN More articles by this author DONALD L. KREUTZER More articles by this author Expand All Advertisement PDF downloadLoading ...