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Prognostic Factors in Invasive Squamous Cell Carcinoma of the Penis: Analysis of 196 Patients Treated at the Brazilian National Cancer Institute

2008; Lippincott Williams & Wilkins; Volume: 180; Issue: 4 Linguagem: Inglês

10.1016/j.juro.2008.06.028

1527-3792

Antônio Augusto Ornellas, Bernardo Lindenberg Braga Nóbrega, Eduardo Wei Kin Chin, Aristóteles Wisnescky, Paulo Cesar Barbosa da Silva, Aline Barros de Santos Schwindt,

Urologic and reproductive health conditions

No AccessJournal of UrologyAdult Urology1 Oct 2008Prognostic Factors in Invasive Squamous Cell Carcinoma of the Penis: Analysis of 196 Patients Treated at the Brazilian National Cancer Institute Antonio Augusto Ornellas, Bernardo Lindenberg Braga Nóbrega, Eduardo Wei Kin Chin, Aristóteles Wisnescky, Paulo Cesar Barbosa da Silva, and Aline Barros de Santos Schwindt Antonio Augusto OrnellasAntonio Augusto Ornellas , Bernardo Lindenberg Braga NóbregaBernardo Lindenberg Braga Nóbrega , Eduardo Wei Kin ChinEduardo Wei Kin Chin , Aristóteles WisnesckyAristóteles Wisnescky , Paulo Cesar Barbosa da SilvaPaulo Cesar Barbosa da Silva , and Aline Barros de Santos SchwindtAline Barros de Santos Schwindt View All Author Informationhttps://doi.org/10.1016/j.juro.2008.06.028AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the role of primary tumor histopathological features for predicting regional metastasis and the prognosis in patients with penile squamous cell carcinoma. Materials and Methods: From April 1996 to January 2007, 202 consecutive patients with penile carcinoma underwent surgical treatment at our institution. Of these patients 196 were studied to identify prognostic factors. All histological specimens were examined by the same pathologist. We considered certain histological parameters, including histological grade, invasion depth, lymphovascular embolization, perineural infiltration, infiltration of the corpus cavernosum or spongiosum, urethral infiltration and koilocytosis. Results: Variables significantly associated with regional metastasis on univariate analysis were stage stratification (p = 0.0338), histological grade (p = 0.0112), invasion depth (0.0114), lymphovascular embolization (p <0.0001), perineural infiltration (p = 0.0092), corpora cavernosa infiltration (p = 0.0005) and koilocytosis (p = 0.0013). In the multivariable model lymphovascular embolization and absent koilocytosis were independent risk factors for lymphatic metastasis (p = 0.001 and 0.009, respectively). We also found a better survival rate in patients with koilocytosis and without lymphovascular embolization (p = 0.001 and 0.005, respectively). Conclusions: Lymphovascular embolization and absent koilocytosis were independent prognostic factors for the risk of lymphatic metastasis. Patients with koilocytosis and without lymphovascular embolization had better 5-year survival. References 1 : Surgical treatment of invasive squamous cell carcinoma of the penis: Brazilian National Cancer Institute long-term experience. J Surg Oncol2008; 97: 487. Google Scholar 2 : Outcomes of initial surveillance of invasive squamous cell carcinoma of the penis and negative nodes. J Urol1996; 155: 1626. 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Link, Google Scholar Departments of Urology and Pathology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil© 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byPhilippou P, Shabbir M, Malone P, Nigam R, Muneer A, Ralph D and Minhas S (2012) Conservative Surgery for Squamous Cell Carcinoma of the Penis: Resection Margins and Long-Term Oncological ControlJournal of Urology, VOL. 188, NO. 3, (803-808), Online publication date: 1-Sep-2012.Gunia S, Erbersdobler A, Hakenberg O, Koch S and May M (2012) p16INK4a is a Marker of Good Prognosis for Primary Invasive Penile Squamous Cell Carcinoma: A Multi-Institutional StudyJournal of Urology, VOL. 187, NO. 3, (899-907), Online publication date: 1-Mar-2012.Souillac I, Rigaud J, Ansquer C, Marconnet L and Bouchot O (2011) Prospective Evaluation of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computerized Tomography to Assess Inguinal Lymph Node Status in Invasive Squamous Cell Carcinoma of the PenisJournal of Urology, VOL. 187, NO. 2, (493-497), Online publication date: 1-Feb-2012.De Paula A, Motta E, Alencar R, Saddi V, da Silva R, Caixeta G, Almeida Netto J and Carneiro M (2011) The Impact of Cyclooxygenase-2 and Vascular Endothelial Growth Factor C Immunoexpression on the Prognosis of Penile CarcinomaJournal of Urology, VOL. 187, NO. 1, (134-140), Online publication date: 1-Jan-2012.Thuret R, Sun M, Abdollah F, Budaus L, Lughezzani G, Liberman D, Morgan M, Johal R, Jeldres C, Latour M, Shariat S, Iborra F, Guiter J, Patard J, Perrotte P and Karakiewicz P (2010) Tumor Grade Improves the Prognostic Ability of American Joint Committee on Cancer Stage in Patients With Penile CarcinomaJournal of Urology, VOL. 185, NO. 2, (501-507), Online publication date: 1-Feb-2011. Volume 180Issue 4October 2008Page: 1354-1359 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordspenile neoplasmsneoplasm metastasislymph nodescarcinomasquamous cellpenisMetricsAuthor Information Antonio Augusto Ornellas More articles by this author Bernardo Lindenberg Braga Nóbrega More articles by this author Eduardo Wei Kin Chin More articles by this author Aristóteles Wisnescky More articles by this author Paulo Cesar Barbosa da Silva More articles by this author Aline Barros de Santos Schwindt More articles by this author Expand All Advertisement PDF downloadLoading ...